Deferasirox msds pdf file

Oct 20 section i product and company identification weldon p70 low voc primer for pvc and cpvc plastic pipe low voc primer for pvc and cpvc plastic pipe manufacturer. Dailymed exjade deferasirox tablet, for suspension. Take exjade once daily on an empty stomach at least 30 minutes before food, preferably at the same time each day. Commission regulation eu no 2015830 of 28 may 2015. Export data and price of deferasirox under hs code 2933 zauba. Exjade deferasirox tablets for oral suspension 4, 5. The potential of deferasirox as a novel therapeutic modality. Mds and chronic iron overload due to blood transfusion have. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Exjade deferasirox tablets for oral suspension prescribing information. Handling and storage precautions for safe handling. Most developed countries have similar regulations and requirements. Deferasirox can be prepared from simple commercially available starting materials salicylic acid, salicylamide and 4hydrazinobenzoic acid in the following twostep synthetic sequence.

Deferasirox is a member of the class of triazoles, deferasirox is 1,2,4triazole substituted by a 4carboxyphenyl group at position 1 and by 2hydroxyphenyl groups at positions 3 and 5. Deferasirox inhibited the growth of all four gastric cancer cell lines in a dosedependent and timedependent manner fig. Product name deferasirox product code sc207509 cas no 201530418 pure substancemixture substance 1. List of drug master files dmf of deferasirox active pharmaceutical ingredient api submitted to the u. Deferasirox is rapidly absorbed following oral administration, reaching peak plasma concentrations at 1. Material safety data sheet msds for nonfat dry milk i. Please note that preregistration is required to buy reference standards. May 06, 2015 this is a randomized, openlabel, multicenter, two arm, phase ii study to evaluate treatment compliance and change in serum ferritin of a deferasirox granule formulation and a deferasirox dt formulation in children and adolescents aged. In case of contact, immediately flush eyes with plenty of water. Ips corporation 17109 south main street, gardena, ca 902483127 p. If you are 55 or older, use this medicine deferasirox tablets with care.

View detailed export data, price, monthly trends, major exporting countries, major ports of deferasirox under hs code 2933. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Msds material safety data sheet nfpa national fire protection association niosh national institute for occupational safety and health ntp national toxicology program rapidpatch tm 11. The information provided in this material safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. It describes the physical and chemical properties of the product. Immediately wash skin with soap and plenty of water for at least 15 minutes. The msds is a detailed informational document prepared by the manufacturer or importer of a hazardous chemical. Randomized phase ii trial of deferasirox exjade, icl670, a oncedaily, orallyadministered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. According to the results of its assessment, this substance is not a pbt or a vpvb. Relevant identified uses of the substance or mixture and uses advised against for research use only. Download product insert pdfdownload safety data sheet sds pdf. Buy deferasirox d4 cas 13425758, a labeled tridentate iron chelator, from santa cruz.

Identification of the substancemixture and of the companyundertaking 1. Msds material data safety sheet 8 gram compressed gas n2o filled charger 1. Find out more about the pharmaceutical components and active ingredients that we have on offer for the pharma and veterinary industries. Our azelaic acid is 100% based on vegetable oil sunflower oil or distel oil cardiano mariano. The information and recommendations contained herein are based upon data believed to be correct. Wash hands before breaks and at the end of workday. Calculate doses mgkg per day to the nearest whole tablet.

Deferasirox according to regulation ec no 19072006, annex ii, as amended. Feb 20, 2020 have a hearing test before starting this medicine deferasirox tablets and while you take this medicine deferasirox tablets. Product identifier product name deferasirox product number fb20882. Controlled clinical trials of exjade in patients with myelodysplastic syndromes.

Material safety data sheet associated industries inc. Buy deferasiroxd4 cas 13425758, a labeled tridentate iron chelator, from santa cruz. Flammability of the product autoignition temperature not available. M, all subsequent experiments were performed using these cells. Deferasirox has a survival benefit for sio leukemia murine model in terms of iron chelation and antileukemic therapy3. Have eyes examined and tested by medical personnel. Do not take exjade with aluminumcontaining antacid products. A safety data sheet sds, material safety data sheet msds, or product safety data sheet psds are documents that list information relating to occupational. Exjade is also indicated for the treatment of chronic iron overload requiring chelation therapy when deferoxamine therapy is contraindicated or inadequate in.

Partb simultaneous reverse phase high performance liquid. The recommended initial daily dose of exjade is 20 mgkg body weight. Deferasirox marketed as exjade, desirox, defrijet, desifer, rasiroxpine and jadenu is an oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving longterm blood transfusions for conditions such as betathalassemia and other chronic anemias. It is the users obligation to evaluate and use this product safely and to comply with all applicable laws and regulations. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving longterm blood transfusions. S705 january 2009 with 32 reads how we measure reads. List of drug master files dmf of cefuroxime axetil active pharmaceutical ingredient api submitted to the u. Msds material data safety sheet 8 gram compressed gas n2o.

Nov 18, 2019 a trial conducted in treatment naive pediatric patients, 2 to deferasirox tablets for oral suspension, 125 mg, 250 mg, and 500 mg. Cefuroxime axetil api dmfs us drug master file dmf. First aid measures description of first aid measures. Deferasirox api dmfs us drug master file dmf details. Pharmaceutical component list active pharmaceutical ingredients. Study to evaluate treatment compliance, efficacy and safety. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. List of drug master files dmf of active pharmaceutical ingredients apis submissions by msn laboratories pvt ltd to the u. Deferasirox cas 201530418 scbt santa cruz biotechnology. In case of contact, immediately flush skin with plenty of water. These products are carbon oxides co, co2, and other toxic compounds nitrogen oxides, isocyanate vapors. Safety data sheet california carb compliant 1 identification product name. Deferasirox is highly protein bound 99%, almost exclusively to.

Material safety data sheet prepared according to 29 cfr 1910. Sds of deferasirox, safety data sheets, cas 201530418. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. We believe the information it contains to be correct but cannot guarantee its accuracy or completeness. Lubricant, penetrant, drives out moisture, removes and protects surfaces from corrosion restrictions on use. This material safety data sheet and the information it contains are offered to you in good faith as accurate. Two molecules of deferasirox are capable of binding to 1 atom of iron which are subsequently eliminated by fecal excretion. Preparation of the 22hydroxyphenyl1, 3 benzoxazinone compound 2. Do not take antacids that have aluminum in them with this medicine deferasirox tablets.

Msn laboratories pvt ltd dmfs us drug master file dmf. Since the ic 50 of deferasirox at 72 h was the lowest in ags cells less than 10. M of deferasirox for 24 or 48 h, and proliferation is determined by an mtt assay2. Hazard identification classification according to regulation no 12722008ec company. A material safety data sheet msds is required under the u. If youre not able to select an item from this list, it means the item is restricted and cannot be ordered online as we first need to ensure that dea requirements are fulfilled.

1379 599 821 871 1285 1333 524 1194 860 808 349 186 1137 1051 809 1073 1239 371 57 1483 774 1015 1527 337 106 402 61 1400 361 1507 1547 157 1455 1240 61 1195 616 1148 679 811 245 1367 191 762 1147